Sahih al-Bukhari 309

Ishaq narrated to us: Khalid ibn Abd Allah narrated to us, from Khalid, from Ikrimah, from Aishah, that the Prophet performed i‘tikaf with one of his wives while she was experiencing prolonged bleeding. She would see blood, and sometimes she placed a basin beneath her to catch it. He also related that Aishah saw safflower-colored water and said, ‘It seems this is something that so-and-so used to experience.’